Super silyl group for a sequential diastereoselective aldol-polyhalomethyllithium addition reaction

被引：21

作者：

Boxer, Matthew B. ^{[1
]}

Yamamoto, Hisashi ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 03期

关键词：

D O I：

10.1021/ol702825p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The super silyl group governs high diastereoselectivity and yields for a sequential aldol-polyhalomethyllithium addition reaction. This unique silyl group is necessary to obtain the diastereoselectivities associated with this-sequential reaction, capable of generating two new stereocenters. alpha-Polyhalomethylcarbinols are generated with the simple and inexpensive dihalomethanes and trihalomethanes.

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页码：453 / 455

页数：3

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