In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

被引：107

作者：

Yardley, V

Khan, AA

Martin, MB

Slifer, TR

Araujo, FG

Moreno, SNJ

Docampo, R

Croft, SL

Oldfield, E

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Biophys, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Pathobiol, Mol Parasitol Lab, Urbana, IL 61802 USA

[4] Palo Alto Med Fdn, Dept Infect Dis, Palo Alto, CA 94301 USA

[5] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 03期

关键词：

D O I：

10.1128/AAC.46.3.929-931.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.

引用

页码：929 / 931

页数：3

共 6 条

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