The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei

The in-vitro activities of four anticancer alkyllysophospholipids, ET-18-OCH3 (edelfosine), hexadecylphosphocholine (miltefosine), ilmofosine and SRI 62-834, were determined with ED(50) values for Leishmania donovani and Trypanosoma cruzi amastigotes between 0.2 and 5.0 mu M and for Trypanosoma brucei trypomastigotes between 7.0 and 50.8 mu M. In BALB/c mice miltefosine and ilmofosine were the most active compounds with ED(50) values of 2.9 and 14.5 mg/kg x 5 doses against L. donovani and a suppressive effect on T. cruzi infections at 30 mg/kg x 5 doses.