Mechanisms of immune evasion by tumors

被引：512

作者：

Drake, CG ^{[1
]}

Jaffee, E ^{[1
]}

Pardoll, DM ^{[1
]}

机构：

[1] Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21218 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 90: CANCER IMMUNOTHERAPY | 2006年 / 90卷

关键词：

D O I：

10.1016/S0065-2776(06)90002-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past decade, basic studies in animal models have begun to elucidate the physiological barriers which impede a successful antitumor immune response. These barriers operate at a number of levels, and involve the tumor, the tumor,microenvironment and various Components of the innate and adaptive immune systems. In this review, we discuss the multiple mechanisms by which tumors evade an immune response, with an emphasis on clinically relevant strategies to overcome these inhibitory checkpoints.

引用

页码：51 / 81

页数：31

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