Differential transcription of histone genes in asexual and sexual stages of Plasmodium falciparum

被引：10

作者：

Lobo, CA ^{[1
]}

Kumar, N ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1999年 / 29卷 / 09期

关键词：

cell cycle; histones; Plasmodium falciparum; transcription;

D O I：

10.1016/S0020-7519(99)00090-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Molecular mechanisms of cell-cycle control in Plasmodium falciparum remain poorly understood. We have traced transcription of histones H2A, H2B and H3 as the parasite progresses through different developmental stages-rings, trophozoites, schizonts and gametocyles. Our results show that the ring stage parasites do not appear to synthesise any of the three histones. We also found a markedly elevated level of H3 transcript in the schizont stage parasite, while H2A and H2B were made in approximately equivalent amounts (in trophozoites, schizonts and garnetocytes). Further study might lead to a better understanding of the control elements involved in the regulation of histone levels in Plasmodium as it develops in the erythrocyte. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1447 / 1449

页数：3