A preliminary study on the prevalence of intestinal microsporidiosis in patients with and without gastrointestinal symptoms in Malaysia

被引：12

作者：

Norhayati, M. ^{[1
]}

Azlin, M. ^{[1
]}

Al-Mekhlafi, M. Hesham ^{[1
]}

Anisah, N. ^{[1
]}

Aini, U. Nor ^{[2
]}

Fatmah, M. S. ^{[1
]}

Rozlida, A. R. ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Med, Dept Parasitol, Kuala Lumpur 50300, Malaysia

[2] Univ Kebangsaan Malaysia, Fac Med, Dept Pathol, Kuala Lumpur 50300, Malaysia

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 102卷 / 12期

关键词：

Microsporidiosis; Microsporidia; Gastrointestinal diseases; Immunocompetence; Immunosuppressive agents; Malaysia;

D O I：

10.1016/j.trstmh.2008.05.019

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

An observational study was carried out to establish the existence of intestinal microsporidiosis among patients with and without gastrointestinal symptoms in Hospital Universiti Kebangsaan Malaysia, Malaysia. A total of 893 faecal specimens from hospitalized patients were examined for microsporidia using a modification of the usual Gram-chromotrope stain technique. One hundred and sixteen (13.0%) patients were positive for microsporidia: 84 (72.4%), 27 (23.3%) and 5 (4.3%) were tow, moderate and high excreters of microsporidia spores, respectively. Of the 91 patients with available medical records, microsporidiosis was commonly observed in children aged 0-6 years (26.4%) and adults aged >= 31 years (57.2%). About one-third of this infection was observed in immunocompetent individuals. Among the immunosuppressive group, microsporidia were observed to be more prevalent in patients with haematological malignancy or a combination of malignancy and diabetes mellitus. About 74% of the patients who had microsporidia in their faeces had gastrointestinal symptoms, which could be related to infections or induced by immunosuppressive therapy. The role of microsporidia in causing gastrointestinal symptoms in this population is as yet unclear. (c) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：1274 / 1278

页数：5

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