Genetics and evolution of Neisseria meningitidis: Importance for the epidemiology of meningococcal disease

被引：85

作者：

Caugant, Dominique A. ^{[1
,2
]}

机构：

[1] Norwegian Inst Publ Hlth, Dept Bacteriol & Immunol, Collaborating Ctr Reference & Res Meningococci, WHO, NO-0403 Oslo, Norway

[2] Univ Oslo, Dept Oral Biol, NO-0316 Oslo, Norway

来源：

INFECTION GENETICS AND EVOLUTION | 2008年 / 8卷 / 05期

关键词：

Neisseria meningitidis; Molecular epidemiology; Population biology; Multilocus sequence typing;

D O I：

10.1016/j.meegid.2008.04.002

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Meningococcal disease is a life-threatening illness occurring worldwide with incidence rates varying from 1 to 1000 cases per 100 000. The causative organism, Neisseria meningitidis, is a normal commensal of humans. While strains associated with asymptomatic carriage are highly diverse, a few hyper-invasive genetic clones of the species may spread rapidly through human populations, resulting in countrywide epidemics of meningococcal meningitis. N. meningitidis fitness for spread and colonization is directly linked to the capability of the bacterium to change its genome and adapt to its environment, by means of a variety of genetic mechanisms. This review addresses some of the impacts of the evolutionary potential of N. meningitidis on the occurrence of meningococcal disease. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：558 / 565

页数：8

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