A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

被引：90

作者：

Nishiyama, Y

Hirota, T

Morisaki, T

Hara, T

Marumoto, T

Iida, S

Makino, K

Yamamoto, H

Hiraoka, T

Kitamura, N

Saya, H

机构：

[1] Kumamoto Univ, Sch Med, Dept Tumor Genet & Biol, Kumamoto 8600811, Japan

[2] Kumamoto Univ, Dept Surg 1, Kumamoto 8600811, Japan

[3] Kumamoto Univ, Sch Med, Dept Pharmacol, Kumamoto 8600811, Japan

来源：

FEBS LETTERS | 1999年 / 459卷 / 02期

关键词：

centrosome; mitotic spindle; Cdc2; midbody; nocodazole; chromosome; 6q;

D O I：

10.1016/S0014-5793(99)01224-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ne identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1, The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis, Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase, These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.

引用

页码：159 / 165

页数：7

共 34 条

[1] Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis [J].