Molecular cloning of the human rad gene: Gene structure and complete nucleotide sequence

被引：4

作者：

Caldwell, JS

Moyers, JS

Doria, A

Reynet, C

Kahn, RC

机构：

[1] HARVARD UNIV,SCH MED,DIV RES,JOSLIN DIABET CTR,BOSTON,MA 02215

[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02215

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1996年 / 1316卷 / 03期

关键词：

GTPase; muscle; MyoD; Ras;

D O I：

10.1016/0925-4439(96)00034-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated and sequenced human genomic DNA clones encoding the Ras-related GTP-binding protein, Rad. The gene spans 3.75 kb and consists of five exons and four introns. Translation initiates from the first of two in-frame methionine residues in the second exon. Several potential transcription cis-elements were revealed throughout the 1.7 kb 5'-flanking region, including 'E box' and CArG binding sites for regulators of transcription in muscle.

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页码：145 / 148

页数：4

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