Lessons Learned From Lung Cancer Genomics: The Emerging Concept of Individualized Diagnostics and Treatment

被引：93

作者：

Buettner, Reinhard ^{[1
]}

Wolf, Juergen ^{[1
]}

Thomas, Roman K. ^{[1
]}

机构：

[1] Univ Cologne, Ctr Integrated Oncol Koln Bonn, D-50931 Cologne, Germany

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2013年 / 31卷 / 15期

关键词：

ACQUIRED-RESISTANCE; EGFR MUTATIONS; IRREVERSIBLE INHIBITORS; KINASE INHIBITORS; DRUG-RESISTANCE; GENE-MUTATIONS; RECEPTOR GENE; GEFITINIB; ERLOTINIB; ADENOCARCINOMA;

D O I：

10.1200/JCO.2012.45.9867

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The advent of novel therapeutics that specifically target signaling pathways activated by genetic alterations has revolutionized the way patients with lung cancer are treated. Although only few and largely ineffective chemotherapeutic regimens were available 10 years ago, a lung tumor diagnosed today requires extensive pathologic subtyping and diagnosis of genome alterations to afford more effective treatment (eg, in EGFR-mutant adenocarcinoma). This change of paradigm has several profound implications, ranging from preclinical work on the mechanism of action to a novel, more biologically oriented taxonomy and from genome diagnostics to trial design. Here, we have summarized these developments into six conceptual paradigms that illustrate the transition from empirical cancer medicine to mechanistically based individualized oncology.

引用

页码：1858 / 1865

页数：8

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