The PE multigene family: a 'molecular mantra' for mycobacteria

被引：185

作者：

Brennan, MJ

Delogu, G

机构：

[1] Food & Drug Adm, Ctr Biol Evaluat & Res, Lab Mycobacterial Dis & Cellular Immunol, Bethesda, MD 20892 USA

[2] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy

来源：

TRENDS IN MICROBIOLOGY | 2002年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0966-842X(02)02335-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.

引用

页码：246 / 249

页数：4

共 21 条

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