Nickel-catalyzed asymmetric cross-couplings of racemic propargylic halides with arylzinc reagents

被引：174

作者：

Smith, Sean W. ^{[1
]}

Fu, Gregory C. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 38期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1021/ja805165y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A stereoconvergent method for the catalytic asymmetric Negishi cross-coupling of racemic secondary propargylic halides with arylzinc reagents has been developed. Neither family of compounds has previously been shown to be a suitable partner in such coupling processes. From a practical point of view, it is noteworthy that the catalyst components (NiCl2 glyme and pybox ligand 1) are commercially available.

引用

页码：12645 / +

页数：4

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