Catalytic asymmetric Hiyama cross-couplings of racemic α-bromo esters

被引：223

作者：

Dai, Xing ^{[1
]}

Strotman, Neil A. ^{[1
]}

Fu, Gregory C. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 11期

关键词：

D O I：

10.1021/ja8009428

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first catalytic asymmetric cross-coupling of alpha-halo carbono compounds with aryl metal reagents has been developed, thereby generating synthetically useful alpha-aryl carboxylic acid derivatives in good enantiomeric excess. The method can also be applied to enantioselective alkenylation reactions.

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页码：3302 / +

页数：3

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