Homeostasis of Naive and Memory T Cells

被引:931
作者
Surh, Charles D. [1 ]
Sprent, Jonathan [2 ]
机构
[1] Scripps Res Inst, La Jolla, CA 92037 USA
[2] Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia
关键词
D O I
10.1016/j.immuni.2008.11.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The peripheral mature T cell pool is regulated by complex homeostatic mechanisms. Naive T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling from contact with major histocompatibility complex (MHC), which sustain expression of antiapoptotic molecules and allow the cells to survive in interphase. Competition for these ligands declines when T cell numbers are reduced and causes residual naive T cells to proliferate and differentiate into memory-like cells. This memory cell population is thus heterogeneous and comprised of cells derived from responses to both foreign and self-antigens. Typical memory cells are kept alive and induced to divide intermittently by a mixture of IL-7 and IL-15. This review highlights recent advances in how naive and memory T cell homeostasis is regulated.
引用
收藏
页码:848 / 862
页数:15
相关论文
共 134 条
[1]   IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].
Aujla, Shean J. ;
Chan, Yvonne R. ;
Zheng, Mingquan ;
Fei, Mingjian ;
Askew, David J. ;
Pociask, Derek A. ;
Reinhart, Todd A. ;
McAllister, Florencia ;
Edeal, Jennifer ;
Gaus, Kristi ;
Husain, Shahid ;
Kreindler, James L. ;
Dubin, Patricia J. ;
Pilewski, Joseph M. ;
Myerburg, Mike M. ;
Mason, Carol A. ;
Iwakura, Yoichiro ;
Kolls, Jay K. .
NATURE MEDICINE, 2008, 14 (03) :275-281
[2]   Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection [J].
Bar, Joshua J. ;
Khanna, Kamal M. ;
Lefrancois, Leo .
IMMUNITY, 2008, 28 (06) :859-869
[3]   Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells [J].
Becker, TC ;
Wherry, EJ ;
Boone, D ;
Murali-Krishna, K ;
Antia, R ;
Ma, A ;
Ahmed, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (12) :1541-1548
[4]   IL-15 promotes the survival of naive and memory phenotype CD8+ T cells [J].
Berard, M ;
Brandt, K ;
Paus, SB ;
Tough, DF .
JOURNAL OF IMMUNOLOGY, 2003, 170 (10) :5018-5026
[5]   Helping the CD8+ T-cell response [J].
Bevan, MJ .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (08) :595-602
[6]   Estimating the precursor frequency of naive antigen-specific CD8 T cells [J].
Blattman, JN ;
Antia, R ;
Sourdive, DJD ;
Wang, XC ;
Kaech, SM ;
Murali-Krishna, K ;
Altman, JD ;
Ahmed, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :657-664
[7]   Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist bim [J].
Bouillet, P ;
Cory, S ;
Zhang, LC ;
Strasser, A ;
Adams, JM .
DEVELOPMENTAL CELL, 2001, 1 (05) :645-653
[8]   Selective stimulation of T cell subsets with antibody-cytokine immune complexes [J].
Boyman, O ;
Kovar, M ;
Rubinstein, MP ;
Surh, CD ;
Sprent, J .
SCIENCE, 2006, 311 (5769) :1924-1927
[9]   A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells [J].
Boyman, Onur ;
Cho, Jae-Ho ;
Tan, Joyce T. ;
Surh, Charles D. ;
Sprent, Jonathan .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (07) :1817-1825
[10]   Do CD8 effector cells need IL-7R expression to become resting memory cells? [J].
Buentke, Eva ;
Mathiot, Anne ;
Tolaini, Mauro ;
Di Santo, James ;
Zamoyska, Rose ;
Seddon, Benedict .
BLOOD, 2006, 108 (06) :1949-1956