Acetophenone glycosides from thyme (Thymus vulgaris L.)

被引：23

作者：

Wang, MF

Kikuzaki, H

Lin, CC

Kahyaoglu, A

Huang, MT

Nakatani, N

Ho, CT ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[2] Rutgers State Univ, Coll Pharm, Dept Biol Chem, Canc Res Lab, Piscataway, NJ 08855 USA

[3] Osaka City Univ, Dept Food & Nutr, Osaka 558, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1999年 / 47卷 / 05期

关键词：

thyme; acetophenone glycoside; Thymus vulgaris L;

D O I：

10.1021/jf981282d

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Four acetophenone glycosides were isolated from the butanol-soluble fraction of thyme extracts. Their structures were determined by spectral methods (MS, NMR, and 2D-NMR). Among them, two new compounds, 4-hydroxyacetophenone 4-O-[5-O-(3,5-dimethoxy-4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1-->2)-beta-D-glucopyranoside (1) and 4-hydroxyacetophenone 4-O-[5-O-(4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1-->2)-beta-D-glucopyranoside (2), were determined. Compound 1 showed weak cytotoxicity, inhibiting DNA synthesis of human leukemia cells.

引用

页码：1911 / 1914

页数：4

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