Variant Creutzfeldt-Jakob disease

被引:404
作者
Collinge, J
机构
[1] St Marys Hosp, Imperial Coll Sch Med, MRC, Prion Unit, London W2 1PG, England
[2] St Marys Hosp, Imperial Coll Sch Med, Dept Neurogenet, London W2 1PG, England
[3] St Marys Hosp, Dept Neurol, London W2 1PG, England
关键词
D O I
10.1016/S0140-6736(99)05128-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
It is clear that the prion strain causing bovine spongiform encephalopathy (BSE) in cattle has infected human beings, manifesting itself as a novel human prion disease, variant Creutzfeldt-Jakob disease (CjD). Studies of the incubation periods seen in previous epidemics of human prion disease and of the effect of transmission barriers limiting spread of these diseases between species, suggest that the early variant CID cases may have been exposed during the preclinical phase of the BSE epidemic. It must therefore be considered that many cases may follow from later exposure in an epidemic that would be expected to evolve over decades. Since the number of people currently incubating this disease is unknown, there are concerns that prions might be transmitted iatrogenically via blood transfusion, tissue donation, and, since prions resist routine sterilisation, contamination of surgical instruments. Such risks remain unquantified. Although variant CJD can be diagnosed during life by tonsil biopsy, a prion-specific blood test is needed to assess and manage this potential threat to public health. The theoretical possibility that BSE prions might have transferred to other species and continue to present a risk to human health cannot be excluded at present.
引用
收藏
页码:317 / 323
页数:7
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