Functional gene polymorphisms in Canadian Aboriginal populations with high rates of tuberculosis

被引：68

作者：

Larcombe, Linda A. ^{[1
,2
]}

Orr, Pamela H. ^{[1
,3
,4
]}

Lodge, Andrew M. ^{[4
]}

Brown, Jodie S. ^{[4
]}

Dembinski, Iga J. ^{[5
]}

Milligan, Leisel C. ^{[3
]}

Larcombe, Erin A. ^{[3
]}

Martin, Bruce D. ^{[4
]}

Nickerson, Peter W. ^{[3
,5
]}

机构：

[1] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada

[2] Univ Manitoba, Dept Anthropol, Winnipeg, MB R3E 0W3, Canada

[3] Univ Manitoba, Dept Med, Winnipeg, MB R3E 0W3, Canada

[4] Univ Manitoba, Dept Community Hlth Sci, JA Hildes No Med Unit, Winnipeg, MB R3E 0W3, Canada

[5] Diagnost Serv Manitoba Inc, Transplant Immunol Lab, Winnipeg, MB, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 08期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1086/592049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dene cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dene and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-gamma (+874), and tumor necrosis factor-alpha (-308) and high production of monocyte chemoattractant protein (MCP)-1 (-2518) and interleukin (IL)-6 (-174). Given the roles played by IFN-gamma and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dene.

引用

页码：1175 / 1179

页数：5

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