The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

被引：247

作者：

Gentile, F. ^{[1
,2
]}

Chiappini, C. ^{[4
]}

Fine, D. ^{[4
]}

Bhavane, R. C. ^{[1
]}

Peluccio, M. S. ^{[1
,7
]}

Cheng, M. Ming-Cheng ^{[1
]}

Liu, X. ^{[1
]}

Ferrari, M. ^{[1
,5
,6
]}

Decuzzi, P. ^{[1
,2
,3
]}

机构：

[1] Univ Texas Hlth Sci Ctr, Houston, TX 77031 USA

[2] Magna Graecia Univ Catanzaro, BioNEM Ctr Bio Nanotechnol & Engn Med, I-88100 Catanzaro, Italy

[3] Politecn Bari, CEMEC Ctr Excellence Computat Mech, Bari, Italy

[4] Univ Texas Austin, Austin, TX 78712 USA

[5] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA

[6] Rice Univ, Houston, TX 77030 USA

[7] Politecn Torino, Dipartimento Meccan, I-10129 Turin, Italy

来源：

JOURNAL OF BIOMECHANICS | 2008年 / 41卷 / 10期

关键词：

particle dynamics; sedimentation; fluidic chamber; drug delivery;

D O I：

10.1016/j.jbiomech.2008.03.021

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation. Silica spherical particles, quasi-hemispherical and discoidal silicon particles have been perfused in a parallel plate flow chamber. The effect of the shape and density on their margination propensity has been investigated at different physiologically relevant shear rates S. Simple scaling laws have been derived showing that the number n of marginating particles scales as S-0.63 for the spheres; S-0.85 for discoidal and S-1 for quasi-hemispherical particles. regardless of their density and size. Within the range considered for the shear rate, discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles. These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2312 / 2318

页数：7

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