Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila

被引:97
作者
Olsen, Shawn R. [1 ]
Wilson, Rachel I. [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
关键词
D O I
10.1016/j.tins.2008.07.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Genetic screens in Drosophila have identified many genes involved in neural development and function. However, until recently, it has been impossible to monitor neural signals in Drosophila central neurons, and it has been difficult to make specific perturbations to central neural circuits. This has changed in the past few years with the development of new tools for measuring and manipulating neural activity in the fly. Here we review how these new tools enable novel conceptual approaches to 'cracking circuits' in this important model organism. We discuss recent studies aimed at defining the cognitive demands on the fly brain, identifying the cellular components of specific neural circuits, mapping functional connectivity in those circuits and defining causal relationships between neural activity and behavior.
引用
收藏
页码:512 / 520
页数:9
相关论文
共 100 条
[41]   Homeostatic matching and nonlinear amplification at identified central synapses [J].
Kazama, Hokto ;
Wilson, Rachel I. .
NEURON, 2008, 58 (03) :401-413
[42]   Conditional modification of behavior in drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons [J].
Kitamoto, T .
JOURNAL OF NEUROBIOLOGY, 2001, 47 (02) :81-92
[43]   Translation of sensory input into behavioral output via an olfactory system [J].
Kreher, Scott A. ;
Mathew, Dennis ;
Kim, Junhyong ;
Carlson, John R. .
NEURON, 2008, 59 (01) :110-124
[44]   Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis [J].
Lee, T ;
Luo, LQ .
NEURON, 1999, 22 (03) :451-461
[45]   Remote control of behavior through genetically targeted photostimulation of neurons [J].
Lima, SQ ;
Miesenböck, G .
CELL, 2005, 121 (01) :141-152
[46]   Distinct memory traces for two visual features in the Drosophila brain [J].
Liu, G ;
Seiler, H ;
Wen, A ;
Zars, T ;
Ito, K ;
Wolf, R ;
Heisenberg, M ;
Liu, L .
NATURE, 2006, 439 (7076) :551-556
[47]   Bilateral olfactory sensory input enhances chemotaxis behavior [J].
Louis, Matthieu ;
Huber, Thomas ;
Benton, Richard ;
Sakmar, Thomas P. ;
Vosshall, Leslie B. .
NATURE NEUROSCIENCE, 2008, 11 (02) :187-199
[48]   Combinatorial methods for refined neuronal gene targeting [J].
Luan, Haojiang ;
White, Benjamin H. .
CURRENT OPINION IN NEUROBIOLOGY, 2007, 17 (05) :572-580
[49]   Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila [J].
Luan, HJ ;
Lemon, WC ;
Peabody, NC ;
Pohl, JB ;
Zelensky, PK ;
Wang, D ;
Nitabach, MN ;
Holmes, TC ;
White, BH .
JOURNAL OF NEUROSCIENCE, 2006, 26 (02) :573-584
[50]   Genetic dissection of neural circuits [J].
Luo, Liqun ;
Callaway, Edward M. ;
Svoboda, Karel .
NEURON, 2008, 57 (05) :634-660