Marine Natural Products as Lead Anti-HIV Agents

被引：43

作者：

Gochfeld, D. J. ^{[1
,2
]}

El Sayed, K. A. ^{[1
,2
]}

Yousaf, M. ^{[1
,2
]}

Hu, J. F. ^{[1
,2
]}

Bartyzel, P. ^{[1
,2
]}

Dunbar, D. C. ^{[1
,2
]}

Wilkins, S. P. ^{[1
,2
]}

Zjawiony, J. K. ^{[1
,2
]}

Schinazi, R. F. ^{[3
,4
]}

Wirtz, S. Schlueter ^{[3
,4
]}

Tharnish, P. M. ^{[3
,4
]}

Hamann, M. T. ^{[1
,2
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, POB 1848, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[3] Emory Univ, Sch Med, Atlanta, GA 30033 USA

[4] Vet Affairs Med Ctr, Atlanta, GA 30033 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

AIDS; HIV; marine natural products; structure-activity relationships; macrolides; modified peptides; alkaloids;

D O I：

10.2174/1389557033487962

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.

引用

页码：401 / 424

页数：24

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