Plague Detection by Anti-carbohydrate Antibodies

被引：28

作者：

Anish, Chakkumkal ^{[1
]}

Guo, Xiaoqiang ^{[1
]}

Wahlbrink, Annette ^{[1
]}

Seeberger, Peter H. ^{[1
,2
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, D-14424 Potsdam, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 36期

关键词：

lipopolysaccharides; antibodies; oligosaccharides; pathogen detection; yersinia pestis; YERSINIA-PESTIS; LIPOPOLYSACCHARIDE; VACCINES;

D O I：

10.1002/anie.201301633

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The sugar coat of "Black Death" betrays it. The plague can be detected by monoclonal anti-carbohydrate antibodies. In a new technique, a plague-specific oligosaccharide antigen (see structure) is synthesized. With the help of lipopolysaccharide (LPS)-specific monoclonal antibodies (mAbs), the presence of the plague pathogen Yersinia pestis can then be detected in serum from patients by using a glycan microarray. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9524 / 9528

页数：5

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