INTERFEROME: the database of interferon regulated genes

被引：195

作者：

Samarajiwa, Shamith A. ^{[1
,2
]}

Forster, Sam ^{[1
]}

Auchettl, Katie ^{[1
]}

Hertzog, Paul J. ^{[1
,2
]}

机构：

[1] Monash Univ, Monash Inst Med Res, Ctr Innate Immun & Infect Dis, Clayton, Vic, Australia

[2] CRC Chron Inflammatory Dis, Melbourne, Vic, Australia

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

英国医学研究理事会;

关键词：

MICROARRAY ANALYSIS; STIMULATED GENES; IFN-ALPHA; FUNCTIONAL ANNOTATION; EXPRESSION; CELLS; BETA; IDENTIFICATION; TRANSCRIPTION; RESPONSES;

D O I：

10.1093/nar/gkn732

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

INTERFEROME is an open access database of types I, II and III Interferon regulated genes (http://www.interferome.org) collected from analysing expression data sets of cells treated with IFNs. This database of interferon regulated genes integrates information from high-throughput experiments with annotation, ontology, orthologue sequences from 37 species, tissue expression patterns and gene regulatory information to enable a detailed investigation of the molecular mechanisms underlying IFN biology. INTERFEROME fulfils a need in infection, immunity, development and cancer research by providing computational tools to assist in identifying interferon signatures in gene lists generated by high-throughput expression technologies, and their potential molecular and biological consequences.

引用

页码：D852 / D857

页数：6

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