Gene Ontology: tool for the unification of biology

被引：30060

作者：

Ashburner, M ^{[1
]}

Ball, CA ^{[1
]}

Blake, JA ^{[1
]}

Botstein, D ^{[1
]}

Butler, H ^{[1
]}

Cherry, JM ^{[1
]}

Davis, AP ^{[1
]}

Dolinski, K ^{[1
]}

Dwight, SS ^{[1
]}

Eppig, JT ^{[1
]}

Harris, MA ^{[1
]}

Hill, DP ^{[1
]}

Issel-Tarver, L ^{[1
]}

Kasarskis, A ^{[1
]}

Lewis, S ^{[1
]}

Matese, JC ^{[1
]}

Richardson, JE ^{[1
]}

Ringwald, M ^{[1
]}

Rubin, GM ^{[1
]}

Sherlock, G ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

NATURE GENETICS | 2000年 / 25卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/75556

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genomic sequencing has made it clear that a large fraction of the genes specifying the core biological functions are shared by all eukaryotes. Knowledge of the biological role of such shared proteins in one organism can often be transferred to other organisms. The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing. To this end, three independent ontologies accessible on the World-Wide Web (http://www.geneontology.org) are being constructed: biological process, molecular function and cellular component.

引用

页码：25 / 29

页数：5

共 33 条

[1] The genome sequence of Drosophila melanogaster
Adams, MD
Celniker, SE
Holt, RA
Evans, CA
Gocayne, JD
Amanatides, PG
Scherer, SE
Li, PW
Hoskins, RA
Galle, RF
George, RA
Lewis, SE
Richards, S
Ashburner, M
Henderson, SN
Sutton, GG
Wortman, JR
Yandell, MD
Zhang, Q
Chen, LX
Brandon, RC
Rogers, YHC
Blazej, RG
Champe, M
Pfeiffer, BD
Wan, KH
Doyle, C
Baxter, EG
Helt, G
Nelson, CR
Miklos, GLG
Abril, JF
Agbayani, A
An, HJ
Andrews-Pfannkoch, C
Baldwin, D
Ballew, RM
Basu, A
Baxendale, J
Bayraktaroglu, L
Beasley, EM
Beeson, KY
Benos, PV
Berman, BP
Bhandari, D
Bolshakov, S
Borkova, D
Botchan, MR
Bouck, J
Brokstein, P
[J]. SCIENCE, 2000, 287 (5461) : 2185 - 2195
[2] Automated genome sequence analysis and annotation
Andrade, MA
Brown, NP
Leroy, C
Hoersch, S
de Daruvar, A
Reich, C
Franchini, A
Tamames, J
Valencia, A
Ouzounis, C
Sander, C
[J]. BIOINFORMATICS, 1999, 15 (05) : 391 - 412
[3] The ENZYME database in 2000
Bairoch, A
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (01) : 304 - 305
[4] The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
Bairoch, A
Apweiler, R
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (01) : 45 - 48
[5] The EMBL Nucleotide Sequence Database
Baker, W
van den Broek, A
Camon, E
Hingamp, P
Sterk, P
Stoesser, G
Tuli, MA
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (01) : 19 - 23
[6] Integrating functional genomic information into the Saccharomyces genome database
Ball, CA
Dolinski, K
Dwight, SS
Harris, MA
Issel-Tarver, L
Kasarskis, A
Scafe, CR
Sherlock, G
Binkley, G
Jin, H
Kaloper, M
Orr, SD
Schroeder, M
Weng, S
Zhu, Y
Botstein, D
Cherry, JM
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (01) : 77 - 80
[7] The Protein Information Resource (PIR)
Barker, WC
Garavelli, JS
Huang, HZ
McGarvey, PB
Orcutt, BC
Srinivasarao, GY
Xiao, CL
Yeh, LSL
Ledley, RS
Janda, JF
Pfeiffer, F
Mewes, HW
Tsugita, A
Wu, C
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (01) : 41 - 44
[8] Genome cross-referencing and XREFdb: Implications for the identification and analysis of genes mutated in human disease
Bassett, DE
Boguski, MS
Spencer, F
Reeves, R
Kim, SH
Weaver, T
Hieter, P
[J]. NATURE GENETICS, 1997, 15 (04) : 339 - 344
[9] Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkh121, 10.1093/nar/gkr1065]
[10] GenBank
Benson, DA
Karsch-Mizrachi, I
Lipman, DJ
Ostell, J
Rapp, BA
Wheeler, DL
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (01) : 15 - 18

← 1 2 3 4 →