BRCA1 inhibition of estrogen receptor signaling in transfected cells

被引：396

作者：

Fan, S

Wang, JA

Yuan, R

Ma, Y

Meng, Q

Erdos, MR

Pestell, RG

Yuan, F

Auborn, KJ

Goldberg, ID

Rosen, EM

机构：

[1] Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Radiat Oncol, New Hyde Park, NY 11040 USA

[2] Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Otolaryngol, New Hyde Park, NY 11040 USA

[3] N Shore Univ Hosp, NSUH LIJ Hlth Syst, Dept Radiat Oncol, Manhasset, NY 11030 USA

[4] NIH, Genet & Mol Biol Branch, Natl Human Genome Res Inst, Bethesda, MD 20892 USA

[5] Yeshiva Univ Albert Einstein Coll Med, Dept Dev, Bronx, NY 10461 USA

[6] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Biol, Bronx, NY 10461 USA

[7] Yeshiva Univ Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

来源：

SCIENCE | 1999年 / 284卷 / 5418期

关键词：

D O I：

10.1126/science.284.5418.1354

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutations of the breast cancer susceptibility gene BRCA1 confer increased risk for breast, ovarian, and prostatic cancers, but it is not clear why the mutations are associated with these particular tumor types. In transient transfection assays, BRCA1 was found to inhibit signaling by the Ligand-activated estrogen receptor (ER-alpha) through the estrogen-responsive enhancer element and to block the transcriptional activation function AF-2 of ER-alpha. These results raise the possibility that wild-type BRCA1 suppresses estrogen-dependent transcriptional pathways related to mammary epithelial cell proliferation and that Loss of this ability contributes to tumorigenesis.

引用

页码：1354 / 1356

页数：3