Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives

被引：172

作者：

Chaudhary, P

Kumar, R

Verma, AK ^{[1
]}

Singh, D

Yadav, V

Chhillar, AK

Sharma, GL

Chandra, R

机构：

[1] Univ Delhi, Synthet Organ Chem Res Lab, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India

[2] Inst Genom & Integrat Biol, Delhi 110007, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 06期

关键词：

piperazine; antibacterial; antifungal; cytotoxicity;

D O I：

10.1016/j.bmc.2005.10.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824)and Escherichia coli(MTCCB 1652), and antifungal activity against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds 4d and 6a showed very less toxicity against human erythrocytes. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：1819 / 1826

页数：8

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