Palladium-Catalyzed Arylation and Alkylation of 3,5-Diphenylisoxazole with Boronic Acids via C-H Activation

被引：52

作者：

Chu, Jean-Ho ^{[1
]}

Chen, Chin-Chau ^{[2
]}

Wu, Ming-Jung ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan

[2] Kaohsiung Med Univ, Grad Inst Pharmaceut Sci, Kaohsiung, Taiwan

来源：

ORGANOMETALLICS | 2008年 / 27卷 / 20期

关键词：

D O I：

10.1021/om800606c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A method for stoichiometric C-H activation of 3,5-diphenylisoxazole (1) using Pd(OAc)(2) as a reagent in acetic acid leading to the isoxazole palladacycle I was described. Ortho aryl- and alkyl-substituted 3,5-diphenylisoxazoles 3a-f and 5a-i were synthesized by the reaction of I with various boronic acids 2a-f and 4a-i, respectively. p-Benzoquinone was found to be the best oxidant and 1,4-dioxane the best solvent for the transmetalation-reductive-elimination step of I with boronic acids.

引用

页码：5173 / 5176

页数：4

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