Antigen-specific regulatory T cells - their induction and role in infection

被引：177

作者：

Mills, KHG ^{[1
]}

McGuirk, P ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Biochem, Immune Regulat Res Grp, Dublin 2, Ireland

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

regulatory T cell; pathogen; dendritic cell; IL-10; suppression;

D O I：

10.1016/j.smim.2003.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to the well-established role of natural CD4(+)CD25(+) regulatory T (Tr) cells in the maintenance of tolerance to self-antigens, there is accumulating evidence for distinct populations of Tr cells induced in the periphery after encounter with pathogens and foreign antigens. These antigen-specific T cells, termed Tr1 or Th3 cells, secrete IL-10 and or TGF-beta, but no IL-4 and little or no IFN-gamma, and are induced by semi-mature dendritic cells under the influence of regulatory cytokines, including IL-10, TGF-beta and IL-4. Tr I or Th3 cells are capable of suppressing Th1 and Th2 responses and function in infection to limit pathogen-induced immunpathology, but can also be exploited in therapies for immune-mediated diseases. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：107 / 117

页数：11

共 90 条

[1] The Xid defect imparts susceptibility to experimental murine filariosis - association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine [J].

Al-Qaoud, KM ;

Fleischer, B ;

Hoerauf, A .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (01) :17-25

[2] A unique subpopulation of CD4+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis [J].

Banz, A ;

Peixoto, A ;

Pontoux, C ;

Cordier, C ;

Rocha, B ;

Papiernik, M .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (09) :2419-2428

[3] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[4] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].

Belkaid, Y ;

Piccirillo, CA ;

Mendez, S ;

Shevach, EM ;

Sacks, DL .

NATURE, 2002, 420 (6915) :502-507

[5]

Björkstén B, 1999, CLIN EXP ALLERGY, V29, P342, DOI 10.1046/j.1365-2222.1999.00560.x

[6] Natural versus adaptive regulatory T cells [J].

Bluestone, JA ;

Abbas, AK .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (03) :253-257

[7] IL-10-producing T cells suppress immune responses in anergic tuberculosis patients [J].

Boussiotis, VA ;

Tsai, EY ;

Yunis, EJ ;

Thim, S ;

Delgado, JC ;

Dascher, CC ;

Berezovskaya, A ;

Rousset, D ;

Reynes, JM ;

Goldfeld, AE .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (09) :1317-1324

[8] Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes [J].

Brady, MT ;

MacDonald, AJ ;

Rowan, AG ;

Mills, KHG .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (12) :3448-3457

[9] Novel IL-12 family members shed light on the orchestration of Th1 responses [J].

Brombacher, F ;

Kastelein, RA ;

Alber, G .

TRENDS IN IMMUNOLOGY, 2003, 24 (04) :207-212

[10] Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis [J].

Bynoe, MS ;

Evans, JT ;

Viret, C ;

Janeway, CA .

IMMUNITY, 2003, 19 (03) :317-328

← 1 2 3 4 5 6 7 8 9 →