Antigen-specific regulatory T cells - their induction and role in infection

被引：177

作者：

Mills, KHG ^{[1
]}

McGuirk, P ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Biochem, Immune Regulat Res Grp, Dublin 2, Ireland

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

regulatory T cell; pathogen; dendritic cell; IL-10; suppression;

D O I：

10.1016/j.smim.2003.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to the well-established role of natural CD4(+)CD25(+) regulatory T (Tr) cells in the maintenance of tolerance to self-antigens, there is accumulating evidence for distinct populations of Tr cells induced in the periphery after encounter with pathogens and foreign antigens. These antigen-specific T cells, termed Tr1 or Th3 cells, secrete IL-10 and or TGF-beta, but no IL-4 and little or no IFN-gamma, and are induced by semi-mature dendritic cells under the influence of regulatory cytokines, including IL-10, TGF-beta and IL-4. Tr I or Th3 cells are capable of suppressing Th1 and Th2 responses and function in infection to limit pathogen-induced immunpathology, but can also be exploited in therapies for immune-mediated diseases. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：107 / 117

页数：11

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