Modeling human hematopoietic cell development from pluripotent stem cells

被引：32

作者：

Kardel, Melanie D.

Eaves, Connie J. ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

来源：

EXPERIMENTAL HEMATOLOGY | 2012年 / 40卷 / 08期

关键词：

BONE MORPHOGENETIC PROTEIN-4; COLONY-FORMING CELLS; RED-BLOOD-CELLS; YOLK-SAC; IN-VITRO; PRIMITIVE STREAK; MOUSE EMBRYOS; GROWTH-FACTOR; FETAL LIVER; IPS CELLS;

D O I：

10.1016/j.exphem.2012.04.001

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Understanding the steps and cues that allow hematopoietic cells to be generated during development holds great clinical as well as biological interest. Analysis of these events in mice has provided many important insights into the processes involved, but features that might be unique to humans remain challenging to elucidate because they cannot be studied directly in vivo. Human embryonic stern or induced pluripotent stem cells offer attractive in vitro alternatives to analyze the process. Here we review recent efforts to develop defined and quantitative systems to address outstanding developmental questions against a background of what we know about the development of hematopoietic cells in the fetus and derived from mouse embryonic stem cells. (C) 2012 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc.

引用

页码：601 / 611

页数：11

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