Label-free detection of DNA hybridization using transistors based on CVD grown graphene

被引：171

作者：

Chen, Tzu-Yin ^{[1
]}

Phan Thi Kim Loan ^{[2
]}

Hsu, Chang-Lung ^{[2
]}

Lee, Yi-Hsien ^{[1
]}

Wang, Jacob Tse-Wei ^{[1
]}

Wei, Kung-Hwa ^{[2
]}

Lin, Cheng-Te ^{[1
]}

Li, Lain-Jong ^{[1
]}

机构：

[1] Acad Sinica, Inst Atom & Mol Sci, Taipei 10617, Taiwan

[2] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 30010, Taiwan

来源：

BIOSENSORS & BIOELECTRONICS | 2013年 / 41卷

关键词：

Label-free detection; Liquid-gated transistors; DNA sensing; CVD graphene; Gold-transfer method; FIELD-EFFECT TRANSISTORS; LAYER GRAPHENE; LARGE-AREA; CARBON; MOLECULES; BINDING; LIQUID; SENSOR; FILMS;

D O I：

10.1016/j.bios.2012.07.059

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The high transconductance and low noise of graphene-based field-effect transistors based on large-area monolayer graphene produced by chemical vapor deposition are used for label-free electrical detection of DNA hybridization. The gate materials, buffer concentration and surface condition of graphene have been optimized to achieve the DNA detection sensitivity as low as 1 pM (10(-12) M), which is more sensitive than the existing report based on few-layer graphene. The graphene films obtained using conventional PMMA-assisted transfer technique exhibits PMMA residues, which degrade the sensing performance of graphene. We have demonstrated that the sensing performance of the graphene samples prepared by gold-transfer is largely enhanced (by 125%). (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：103 / 109

页数：7

共 46 条

[1] A self-consistent theory for graphene transport [J].

Adam, Shaffique ;

Hwang, E. H. ;

Galitski, V. M. ;

Das Sarma, S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) :18392-18397

[2] Carbon nanotube field-effect-transistor-based biosensors [J].

Allen, Brett Lee ;

Kichambare, Padmakar D. ;

Star, Alexander .

ADVANCED MATERIALS, 2007, 19 (11) :1439-1451

[3] Network single-walled carbon nanotube-field effect transistors (SWNT-FETs) with increased Schottky contact area for highly sensitive biosensor applications [J].

Byon, HR ;

Choi, HC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (07) :2188-2189

[4] Electrical Probing of Submicroliter Liquid Using Graphene Strip Transistors Built on a Nanopipette [J].

Chen, Chang-Hsiao ;

Lin, Cheng-Te ;

Lee, Yi-Hsien ;

Liu, Keng-Ku ;

Su, Ching-Yuan ;

Zhang, Wenjing ;

Li, Lain-Jong .

SMALL, 2012, 8 (01) :43-46

[5] Electrochemical Gate-Controlled Charge Transport in Graphene in Ionic Liquid and Aqueous Solution [J].

Chen, Fang ;

Qing, Quan ;

Xia, Jilin ;

Li, Jinghong ;

Tao, Nongjian .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (29) :9908-+

[6] Dielectric Screening Enhanced Performance in Graphene FET [J].

Chen, Fang ;

Xia, Jilin ;

Ferry, David K. ;

Tao, Nongjian .

NANO LETTERS, 2009, 9 (07) :2571-2574

[7] Ionic Screening of Charged-Impurity Scattering in Graphene [J].

Chen, Fang ;

Xia, Jilin ;

Tao, Nongjian .

NANO LETTERS, 2009, 9 (04) :1621-1625

[8] Intrinsic Response of Graphene Vapor Sensors [J].

Dan, Yaping ;

Lu, Ye ;

Kybert, Nicholas J. ;

Luo, Zhengtang ;

Johnson, A. T. Charlie .

NANO LETTERS, 2009, 9 (04) :1472-1475

[9] Label-free electronic detection of DNA using simple double-walled carbon nanotube resistors [J].

Dong, Xiaochen ;

Fu, Dongliang ;

Xu, Yanping ;

Wei, Jinquan ;

Shi, Yumeng ;

Chen, Peng ;

Li, Lain-Jong .

JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (26) :9891-9895

[10] Electrical Detection of DNA Hybridization with Single-Base Specificity Using Transistors Based on CVD-Grown Graphene Sheets [J].

Dong, Xiaochen ;

Shi, Yumeng ;

Huang, Wei ;

Chen, Peng ;

Li, Lain-Jong .

ADVANCED MATERIALS, 2010, 22 (14) :1649-+

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