Role of ghrelin axis in colorectal cancer: A novel association

被引：91

作者：

Waseem, Talat ^{[1
]}

Javaid-ur-Rehman ^{[1
]}

Ahmad, Farooq ^{[1
]}

Azam, Muhammad ^{[2
]}

Qureshi, Mansoor Ahmad ^{[2
]}

机构：

[1] Serv Hosp, Dept Surg, SIMS, Lahore, Pakistan

[2] Shaukat Khanum Mem Canc Hosp & Res Ctr, Dept Pathol, Lahore, Pakistan

来源：

PEPTIDES | 2008年 / 29卷 / 08期

关键词：

ghrelin; colorectal cancer; autocrine/paracrine mechanism; cell proliferation;

D O I：

10.1016/j.peptides.2008.03.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Recently discovered orexigenic peptide, ghrelin, which is primarily produced by gastrointestinal tract, has been implicated in the malignant cell proliferation and invasion, presumably through an autocrine/paracrine mechanism. This study was aimed to identify the role of endogenously produced ghrelin in colorectal cancer progression. Malignant intestinal epithelial cells differentially over-express ghrelin receptors and produce more ghrelin as compared to normal human colonocytes, leading to their enhanced proliferative and invasive behavior. Though, systemically available endocrine ghrelin levels in patients with colorectal cancer do not exhibit significant correlation with any tumor stage or grade, however, locally produced autocrine tissue ghrelin strongly correlates both with advancing colorectal malignancy in a stage-dependent manner and BMI of the colorectal patients. We conclude that ghrelin might play an important role in promoting colorectal malignancy. (c) 2008 Elsevier Inc. All rights reserved.

引用

收藏

页码：1369 / 1376

页数：8

相关论文

共 33 条

[1]

Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells [J].

Andreis, PG ;

Malendowicz, LK ;

Trejter, M ;

Neri, G ;

Spinazzi, R ;

Rossi, GP ;

Nussdorfer, GG .

FEBS LETTERS, 2003, 536 (1-3) :173-179

[2]

Ghrelin immunohistochemistry of gastric adenocarcinoma and mucoepidermoid carcinoma of salivary gland [J].

Aydin, S ;

Ozercan, IH ;

Dagli, F ;

Aydin, S ;

Dogru, O ;

Celebi, S ;

Akin, O ;

Guzel, SP .

BIOTECHNIC & HISTOCHEMISTRY, 2005, 80 (3-4) :163-168

[3]

Loss of growth hormone secretagogue receptor 1a and overexpression of type 1b receptor transcripts in human adrenocortical tumors [J].

Barzon, L ;

Pacenti, M ;

Masi, G ;

Stefani, AL ;

Fincati, K ;

Palù, G .

ONCOLOGY, 2005, 68 (4-6) :414-421

[4]

Circulating gastrin and ghrelin levels in patients with colorectal cancer:: Correlation with tumour stage, Helicobacter pylori infection and BMI [J].

D'Onghia, V. ;

Leoncini, R. ;

Carli, R. ;

Santoro, A. ;

Giglioni, S. ;

Sorbellini, F. ;

Marzocca, G. ;

Bernini, A. ;

Campagna, S. ;

Marinello, E. ;

Vannoni, D. .

BIOMEDICINE & PHARMACOTHERAPY, 2007, 61 (2-3) :137-141

[5]

Autocrine proliferative effect of ghrelin on leukemic HL-60 and THP-1 cells [J].

De Vriese, Carine ;

Delporte, Christine .

JOURNAL OF ENDOCRINOLOGY, 2007, 192 (01) :199-205

[6]

Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia [J].

DeBoer, Mark D. ;

Zhu, Xin Xia ;

Levasseur, Peter ;

Meguid, Michael M. ;

Suzuki, Susumu ;

Inui, Akio ;

Taylor, John E. ;

Halem, Heather A. ;

Dong, Jesse Z. ;

Datta, Rakesh ;

Culler, Michael D. ;

Marks, Daniel L. .

ENDOCRINOLOGY, 2007, 148 (06) :3004-3012

[7]

Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a [J].

Delhanty, PJD ;

van der Eerden, BCJ ;

van der Velde, M ;

Gauna, C ;

Pols, HAP ;

Jahr, H ;

Chiba, H ;

van der Lely, AJ ;

van Leeuwen, JPTM .

JOURNAL OF ENDOCRINOLOGY, 2006, 188 (01) :37-47

[8]

Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness [J].

Duxbury, MS ;

Waseem, T ;

Ito, H ;

Robinson, MK ;

Zinner, MJ ;

Ashley, SW ;

Whang, EE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 309 (02) :464-468

[9]

HUMAN COLONOCYTES IN PRIMARY CULTURE - A MODEL TO STUDY EPITHELIAL GROWTH, METABOLISM AND DIFFERENTIATION [J].

FONTI, R ;

LATELLA, G ;

BISES, G ;

MAGLIOCCA, F ;

NOBILI, F ;

CAPRILLI, R ;

SAMBUY, Y .

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 1994, 9 (01) :13-22

[10]

Freeman HJ, 2004, BEST PRACT RES CL GA, V18, P1167, DOI 10.1016/S1521-6918(04)00107-6

← 1 2 3 4 →