Chemokine production and chemokine receptor expression by human glioma cells: Role of CXCL10 in tumour cell proliferation

被引：87

作者：

Maru, Seema V. ^{[1
]}

Holloway, Karen A. ^{[1
]}

Flynn, Geraldine ^{[1
]}

Lancashire, Christine L. ^{[1
]}

Loughlin, A. Jane ^{[1
]}

Male, David K. ^{[1
]}

Romero, Ignacio A. ^{[1
]}

机构：

[1] Open Univ, Dept Life Sci, Immunol & Cell Biol Grp, Milton Keynes MK7 6AA, Bucks, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 199卷 / 1-2期

关键词：

chemokines; glioma; CXCL10; proliferation; ERK;

D O I：

10.1016/j.jneuroim.2008.04.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of chemokine receptors and chemokine production by adult human non-transformed astrocytes, grade Ill astrocytoma and,grade IV glioblastoma tumour cell lines were determined. Here, we show an increased expression of CXCR3 and CXCR4, and a decreased expression of CXCR1 and CCR4 by glioma cells compared to adult human astrocytes. Glioma cells showed increased production of CXCL10, whereas production of other chemokines was decreased (CXCL8, CCL2, CCL5, and CCL22). CXCL10 induced an ERK1/2-dependent increase in [H-3] thymidine uptake. These results suggest that expression of chemokine receptor/ligand Pairs Such as CXCR3/CXCL10 have an important role in the proliferation of glioma cells. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：35 / 45

页数：11

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