Adriamycin-induced changes of creatine kinase activity in vivo and in cardiomyocyte culture

被引：52

作者：

DeAtley, SM

Aksenov, MY

Aksenova, MV

Jordan, B

Carney, JM

Butterfield, DA ^{[1
]}

机构：

[1] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40506 USA

[2] Univ Kentucky, Dept Pharmacol, Lexington, KY 40506 USA

[3] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

[4] Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USA

[5] Centaur Pharmaceut Inc, Sunnyvale, CA 94086 USA

来源：

TOXICOLOGY | 1999年 / 134卷 / 01期

关键词：

adriamycin; oxygen free radicals; creatine kinase; cardiomyocytes; cardiotoxicity;

D O I：

10.1016/S0300-483X(99)00039-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adriamycin (ADM) is an anthracycline anti-neoplastic agent, whose clinical effectiveness is limited by severe Side effects, including cardiotoxicity. The toxic effects of ADM are likely to be the consequence of the generation of free radicals. This study demonstrates that ADM induces significant changes in the activity of the oxidative sensitive enzyme creatine kinase (CK) in the heart in vivo and in a cardiomyocyte culture model. The changes observed are likely to reflect the ability of ADM to damage the plasma membrane of cardiac cells and to induce the direct inactivation of CK. The role for ADM-derived free radicals is one of the possible mechanisms for the CK inactivation observed during the ADM treatment. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：51 / 62

页数：12