Metabolomics Application in Maternal-Fetal Medicine

被引：80

作者：

Fanos, Vassilios ^{[1
,2
]}

Atzori, Luigi ^{[3
]}

Makarenko, Karina ^{[4
]}

Melis, Gian Benedetto ^{[5
]}

Ferrazzi, Enrico ^{[4
]}

机构：

[1] AOU, NICU, Puericulture Inst & Neonatal Sect, I-09124 Cagliari, Italy

[2] Univ Cagliari, I-09124 Cagliari, Italy

[3] Univ Cagliari, Dept Biomed Sci, I-09124 Cagliari, Italy

[4] Univ Milan, Dept Woman Mother & Neonate, Buzzi Hosp, Biomed & Clin Sci Sch Med, I-20122 Milan, Italy

[5] Univ Cagliari, Dept Obstet & Gynecol & Human Reprod Physiopathol, I-09124 Cagliari, Italy

来源：

BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

TRIMESTER AMNIOTIC-FLUID; PHOSPHOGLYCAN P-TYPE; 1ST-TRIMESTER PREDICTION; PRENATAL DISORDERS; PREECLAMPSIA; BIOMARKERS; URINE; NEONATOLOGY; METABONOMICS; FOOTPRINT;

D O I：

10.1155/2013/720514

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, cord blood, placenta, urine, and vaginal secretions. All published papers highlight the strong correlation between biomarkers found in these tissues and fetal malformations, preterm delivery, premature rupture of membranes, gestational diabetes mellitus, preeclampsia, neonatal asphyxia, and hypoxic-ischemic encephalopathy. The aim of this review is to summarize and comment on original data available in relevant published works in order to emphasize the clinical potential of metabolomics in obstetrics in the immediate future.

引用

页数：9

共 46 条

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