Subsurface tumor progression investigated by noninvasive optical second harmonic tomography

被引：60

作者：

Guo, YC

Savage, HE

Liu, F

Schantz, SP

Ho, PP

Alfano, RR

机构：

[1] CUNY City Coll, Dept Phys, Dept Energy, Ctr Excellence Laser Imaging & Canc Diagnost, New York, NY 10031 USA

[2] CUNY City Coll, Dept Elect Engn, Dept Energy, Ctr Excellence Laser Imaging & Canc Diagnost, New York, NY 10031 USA

[3] CUNY, Inst Ultrafast Spect & Lasers, New York State Ctr Adv Technol Ultrafast Photon M, New York, NY 10031 USA

[4] CUNY, Grad Sch, New York, NY 10031 USA

[5] New York Eye & Ear Infirm, New York, NY 10003 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 19期

关键词：

second harmonic generation; optical tomography; histology;

D O I：

10.1073/pnas.96.19.10854

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nonlinear optical imaging with femtosecond (10(-15)-second) laser technology aas used to evaluate the subsurface tumor progression in control, dysplasia, and cancerous 7,12-dimethylbenz[a] anthracene-treated hamster cheek pouch mucosa tissues. Two-dimensional images of hamster cheek pouch mucosa tissues were obtained by scanning the second harmonic Signal at various sagittal and axial positions, The spatial mapping of the second harmonic signals showed depth differentiation between normal, dysplasia, and a more advanced cancerous state, This nonlinear optical method offers a noninvasive in situ imaging tool to the medical community.

引用

页码：10854 / 10856

页数：3

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