Anti-influenza virus drug design: Sialidase inhibitors

被引：17

作者：

Dyason, JC ^{[1
]}

von Itzstein, M ^{[1
]}

机构：

[1] Griffith Univ, Ctr Biomol Sci & Drug Discovery, Southport, Qld 9726, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2001年 / 54卷 / 11期

关键词：

D O I：

10.1071/CH01173

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review will give an overview of the design process behind the development of sialidase inhibitors, which can be used as anti-influenza drugs. Two drugs (Relenza(TM) and Tamiflu(TM)) are already available as prescription drugs and a third (BCX-1812) is currently undergoing third-phase clinical trials. Also, the use of molecular-modelling techniques in the understanding of the mechanism and the prediction of inhibition of this enzyme is reviewed.

引用

页码：663 / 670

页数：8

共 57 条

[1] Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain [J].

Andrews, DM ;

Cherry, PC ;

Humber, DC ;

Jones, PS ;

Keeling, SP ;

Martin, PF ;

Shaw, CD ;

Swanson, S .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (7-8) :563-574

[2] NEW METHOD FOR PREDICTING BINDING-AFFINITY IN COMPUTER-AIDED DRUG DESIGN [J].

AQVIST, J ;

MEDINA, C ;

SAMUELSSON, JE .

PROTEIN ENGINEERING, 1994, 7 (03) :385-391

[3] Hydrophobic benzoic acids as inhibitors of influenza neuraminidase [J].

Atigadda, VR ;

Brouillette, WJ ;

Duarte, F ;

Babu, YS ;

Bantia, S ;

Chand, P ;

Chu, NM ;

Montgomery, JA ;

Walsh, DA ;

Sudbeck, E ;

Finley, J ;

Air, GM ;

Luo, M ;

Laver, GW .

BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (11) :2487-2497

[4] Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent [J].

Atigadda, VR ;

Brouillette, WJ ;

Duarte, F ;

Ali, SM ;

Babu, YS ;

Bantia, S ;

Chand, P ;

Chu, N ;

Montgomery, JA ;

Walsh, DA ;

Sudbeck, EA ;

Finley, J ;

Luo, M ;

Air, GM ;

Laver, GW .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (13) :2332-2343

[5] BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design [J].

Babu, YS ;

Chand, P ;

Bantia, S ;

Kotian, P ;

Dehghani, A ;

El-Kattan, Y ;

Lin, TH ;

Hutchison, TL ;

Elliott, AJ ;

Parker, CD ;

Ananth, SL ;

Horn, LL ;

Laver, GW ;

Montgomery, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (19) :3482-3486

[6] Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir [J].

Bantia, S ;

Parker, CD ;

Ananth, SL ;

Horn, LL ;

Andries, K ;

Chand, P ;

Kotian, PL ;

Dehghani, A ;

El-Kattan, Y ;

Lin, T ;

Hutchison, TL ;

Montgomery, JA ;

Kellog, DL ;

Babu, YS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (04) :1162-1167

[7] 3-DIMENSIONAL STRUCTURE OF INFLUENZA-A N9 NEURAMINIDASE AND ITS COMPLEX WITH THE INHIBITOR 2-DEOXY 2,3-DEHYDRO-N-ACETYL NEURAMINIC ACID [J].

BOSSARTWHITAKER, P ;

CARSON, M ;

BABU, YS ;

SMITH, CD ;

LAVER, WG ;

AIR, GM .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 232 (04) :1069-1083

[8] INFLUENZA-B VIRUS NEURAMINIDASE CAN SYNTHESIZE ITS OWN INHIBITOR [J].

BURMEISTER, WP ;

HENRISSAT, B ;

BOSSO, C ;

CUSACK, S ;

RUIGROK, RWH .

STRUCTURE, 1993, 1 (01) :19-26

[9] THE 2.2-A RESOLUTION CRYSTAL-STRUCTURE OF INFLUENZA-B NEURAMINIDASE AND ITS COMPLEX WITH SIALIC-ACID [J].

BURMEISTER, WP ;

RUIGROK, RWH ;

CUSACK, S .

EMBO JOURNAL, 1992, 11 (01) :49-56

[10]

CHANDLER M, 1995, J CHEM SOC P1, V9, P1173

← 1 2 3 4 5 6 →