Adalimumab treatment may replace or enhance the activity of steroids in steroid-refractory tuberculous meningitis

被引：21

作者：

Lee, Ho-Su ^{[1
]}

Lee, Yumi ^{[1
]}

Lee, Sang-Oh ^{[1
]}

Choi, Sang-Ho ^{[1
]}

Kim, Yang Soo ^{[1
]}

Woo, Jun Hee ^{[1
]}

Kim, Sung-Han ^{[1
]}

机构：

[1] Univ Ulsan, Dept Infect Dis, Asan Med Ctr, Coll Med, Seoul 138736, South Korea

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2012年 / 18卷 / 04期

关键词：

Tuberculosis; Paradoxical reaction; Steroid-refractory; Tumor necrosis factor inhibitor; Adalimumab; THALIDOMIDE; THERAPY;

D O I：

10.1007/s10156-011-0334-y

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We describe a paradoxical response involving the central nervous system in a patient with steroid-refractory tuberculous meningitis that was unresponsive to systemic corticosteroids but was improved with adalimumab. The immunomodulatory effect of tumor necrosis factor inhibitors may have a role in replacing or enhancing the activity of steroids in the management of steroid-refractory tuberculous meningitis.

引用

页码：555 / 557

页数：3

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