Corilagin Protects Against HSV1 Encephalitis Through Inhibiting the TLR2 Signaling Pathways In Vivo and In Vitro

被引：58

作者：

Guo, Yuan-Jin ^{[1
]}

Luo, Tao ^{[1
]}

Wu, Fei ^{[2
]}

Liu, Huan ^{[1
]}

Li, Hua-Rong ^{[3
]}

Mei, Yuan-Wu ^{[1
]}

Zhang, Shu-Ling ^{[3
]}

Tao, Jun-Yan ^{[4
]}

Dong, Ji-Hua ^{[5
]}

Fang, Yuan ^{[1
]}

Zhao, Lei ^{[3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Neurol, Wuhan 430022, Peoples R China

[2] Wuhan Gen Hosp, Dept Neurol, Guangzhou Mil Command, Wuhan 430070, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Infect Dis, Wuhan 430022, Peoples R China

[4] Hubei Univ Chinese Med, Sch Pharm, Wuhan 430065, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Cent Lab, Wuhan 430022, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2015年 / 52卷 / 03期

关键词：

Corilagin; Inflammation; Toll-like receptor 2; Signaling pathways; Herpes simplex virus-1; TOLL-LIKE RECEPTOR-2; PATTERN-RECOGNITION RECEPTORS; IMMUNE-RESPONSES; MICROGLIAL CELLS; ETHANOL EXTRACT; TNF-ALPHA; INNATE; ACTIVATION; INFECTION; INFLAMMATION;

D O I：

10.1007/s12035-014-8947-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In this study, we tried to explore the molecular mechanism that Corilagin protected against herpes simplex virus-1 encephalitis through inhibiting the TLR2 signaling pathways in vivo and in vitro. As a result, Corilagin significantly prevented increase in the levels of TLR2 and its downstream mediators following Malp2 or HSV-1 challenge. On the other hand, in spite of TLR2 knockdown, Corilagin could still significantly suppress the expression of P38 and NEMO, phosphor-P38, and nuclear factor kappa B. The mRNA and protein expression of TLR2 and its downstream mediators in the brain tissue were also significantly lowered in mice treated with Corilagin. In addition, Corilagin inhibited expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 protein. In conclusion, Corilagin shows the potential to protect against HSV-1-induced encephalitis, and the beneficial effects may be mediated by inhibiting TLR2 signaling pathways.

引用

页码：1547 / 1560

页数：14

共 56 条

[1]

Barrenschee Martina, 2010, PLoS One, V5, pe13889, DOI 10.1371/journal.pone.0013889

[2]

Intracellular Toll-like Receptors [J].