In vivo serial diffusion tensor imaging of experimental spinal cord injury

被引:133
作者
Deo, AA
Grill, RJ
Hasan, KM
Narayana, PA
机构
[1] Univ Texas, Sch Med, Dept Diabet & Intervent Imaging, Houston, TX 77030 USA
[2] Univ Texas, Sch Med, Dept Neurosurg, Houston, TX 77030 USA
关键词
spinal cord injury; MRI; DTI; eigenvalues; transverse diffusivity; longitudinal diffusivity;
D O I
10.1002/jnr.20783
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In vivo longitudinal diffusion tensor imaging (DTI) of rodent spinal cord injury (SCI) was carried out over a period of eight weeks post-injury. A balanced, rotationally invariant, alternating gradient polarity icosahedral diffusion encoding scheme was used for an unbiased estimation of the DTI metrics. The fractional anisotropy (FA), diffusivities along (longitudinal), and perpendicular (transverse) to the fiber tracts, were estimated for the ventral, dorsal, and lateral white matter. In all the three regions, the DTI metrics were observed to be significantly different in injured cords relative to the uninjured controls close to the epicenter of the injury. However, these differences gradually disappeared away from the epicenter. The spatio-temporal changes in the DTI metrics showed a recovery pattern that is region specific. Although the temporal trends in the tissue recovery in rostral and caudal sections seem to be similar, overall the DTI metrics were observed to be closer to the normal tissue values in the caudal relative to the rostral sections (rostral-caudal asymmetry). (C) 2006 Wiley-Liss, Inc.
引用
收藏
页码:801 / 810
页数:10
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