Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages

被引:422
作者
Wood, HB [1 ]
Episkopou, V [1 ]
机构
[1] Hammersmith Hosp, Ctr Clin Sci, MRC, Mammalian Neurogenesis Grp, London W12 0NN, England
基金
英国医学研究理事会;
关键词
mouse embryo; Sox1; Sox2; Sox3; HMG box; gastrulation; neural tube; surface ectoderm; gut endoderm;
D O I
10.1016/S0925-4773(99)00116-1
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Whole mount in situ hybridisation was used to study the embryonic expression of the mouse HMG box-containing genes Sox1, Sox2 and Sox3 between 6.5 and 9.0 days post coitum (dpc). Sox2 and Sox3 are expressed in the epiblast and extraembryonic ectoderm of the egg cylinder, becoming restricted to the prospective neural plate and chorion at the onset of gastrulation. Sox3 is upregulated in the posterior ectoderm during late streak and neural plate stages and is concomitantly downregulated in the chorion. Sox1 transcripts are first detected in the neural fold ectoderm at the headfold stage. During early somitogenesis, all three genes are expressed in the neuroectoderm, and Sod and Sox3 are also expressed in the primitive streak ectoderm, gut endoderm and prospective sensory placodes. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:197 / 201
页数:5
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