How to perform and analyse synovial biopsies

被引：26

作者：

Gerlag, Danielle M. ^{[1
]}

Tak, Paul P. ^{[1
,2
,3
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Div Clin Immunol & Rheumatol, NL-1100 DE Amsterdam, Netherlands

[2] Univ Cambridge, Cambridge, England

[3] GlaxoSmithKline, Stevenage, Herts, England

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2013年 / 27卷 / 02期

关键词：

Arthritis; Synovitis; Synovial tissue; Synovial biopsy; Arthroscopy; Synovial biomarkers; Digital image analysis; POLYMERASE-CHAIN-REACTION; RHEUMATOID-ARTHRITIS; ARTHROSCOPIC LAVAGE; GENE-EXPRESSION; CELL INFILTRATE; PROINFLAMMATORY CYTOKINES; INTRAARTICULAR VARIATION; MICROSCOPIC MEASUREMENT; MEMBRANE INFLAMMATION; IMAGE-ANALYSIS;

D O I：

10.1016/j.berh.2013.03.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Although most of the rheumatologic diseases can be diagnosed based on clinical examination combined with additional laboratory and radiographic tests, histological examination of synovial tissue may lead to the correct diagnosis and adjustment of therapy when neoplastic or granulomatous disease, deposition disease or infection in spite of negative synovial fluid culture is suspected. For research purposes synovial tissue analysis is used to investigate the pathological changes of the synovium in studies aimed at elucidating the aetiology and pathogenetic mechanisms involved in arthritis. In addition, the use of synovial biomarkers has been shown to be instrumental in the developmental process of new therapeutics. In this chapter, several minimally invasive techniques for acquiring synovial tissue samples, handling of the tissue and the analysis thereof are described. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：195 / 207

页数：13

共 62 条

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