Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates

被引：26

作者：

Genetta, T

Kadesch, T

机构：

[1] UNIV PENN,MED CTR,DEPT GENET,PHILADELPHIA,PA 19104

[2] UNIV PENN,MED CTR,HOWARD HUGHES MED INST,PHILADELPHIA,PA 19104

来源：

GENE | 1996年 / 169卷 / 02期

关键词：

zinc finger; DNA-binding protein; tissue-specific gene regulation; phylogenetic comparison;

D O I：

10.1016/0378-1119(95)00824-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The nucleotide sequence encoding an approx. 120-kDa transcriptional repressor (MEB1) was determined from a cDNA which was cloned from a mouse brain library. An alignment of the deduced amino-acid sequences of the putative functional domains of MEB1 with those from the human, hamster and chicken homologues reveals a dramatic degree of conservation.

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收藏

页码：289 / 290

页数：2

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