2 DISTINCT TRANSCRIPTION FACTORS THAT BIND THE IMMUNOGLOBULIN ENHANCER MU-E5/KE2 MOTIF

被引：429

作者：

HENTHORN, P ^{[1
]}

KILEDJIAN, M ^{[1
]}

KADESCH, T ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT HUMAN GENET,PHILADELPHIA,PA 19104

来源：

SCIENCE | 1990年 / 247卷 / 4941期

关键词：

D O I：

10.1126/science.2105528

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Activity of the immunoglobulin heavy and κ light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted HFP-1 and ITF-2, that are expressed in a variety of cell types and bind the μE5/κE2 motif found in both heavy and κ light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.

引用

页码：467 / 470

页数：4

共 43 条

[1] ENHANCERS - MECHANISMS OF ACTION AND CELL SPECIFICITY [J].

ATCHISON, ML .

ANNUAL REVIEW OF CELL BIOLOGY, 1988, 4 :127-153

[2] A LYMPHOCYTE-SPECIFIC CELLULAR ENHANCER IS LOCATED DOWNSTREAM OF THE JOINING REGION IN IMMUNOGLOBULIN HEAVY-CHAIN GENES [J].

BANERJI, J ;

OLSON, L ;

SCHAFFNER, W .

CELL, 1983, 33 (03) :729-740

[3] THE HUMAN C-MYC-ONCOGENE - STRUCTURAL CONSEQUENCES OF TRANSLOCATION INTO THE IGH LOCUS IN BURKITT-LYMPHOMA [J].

BATTEY, J ;

MOULDING, C ;

TAUB, R ;

MURPHY, W ;

STEWART, T ;

POTTER, H ;

LENOIR, G ;

LEDER, P .

CELL, 1983, 34 (03) :779-787

[4] IDENTIFICATION OF A YEAST PROTEIN WITH PROPERTIES SIMILAR TO THOSE OF THE IMMUNOGLOBULIN HEAVY-CHAIN ENHANCER-BINDING PROTEIN NF-MU-E3 [J].

BECKMANN, H ;

KADESCH, T .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (10) :4535-4540

[5]

BECKMANN H, IN PRESS GENES DEV, V4

[6] DAUGHTERLESS, A DROSOPHILA GENE ESSENTIAL FOR BOTH NEUROGENESIS AND SEX DETERMINATION, HAS SEQUENCE SIMILARITIES TO MYC AND THE ACHAETE-SCUTE COMPLEX [J].

CAUDY, M ;

VASSIN, H ;

BRAND, M ;

TUMA, R ;

JAN, LY ;

JAN, YN .

CELL, 1988, 55 (06) :1061-1067

[7]

CHURCH GM, 1985, NATURE, V313, P608

[8] B-LINEAGE SPECIFIC INTERACTIONS OF AN IMMUNOGLOBULIN ENHANCER WITH CELLULAR FACTORS INVIVO [J].

EPHRUSSI, A ;

CHURCH, GM ;

TONEGAWA, S ;

GILBERT, W .

SCIENCE, 1985, 227 (4683) :134-140

[9] A TISSUE-SPECIFIC TRANSCRIPTION ENHANCER ELEMENT IS LOCATED IN THE MAJOR INTRON OF A REARRANGED IMMUNOGLOBULIN HEAVY-CHAIN GENE [J].

GILLIES, SD ;

MORRISON, SL ;

OI, VT ;

TONEGAWA, S .

CELL, 1983, 33 (03) :717-728

[10] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS [J].

GORMAN, CM ;

MOFFAT, LF ;

HOWARD, BH .

MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) :1044-1051

← 1 2 3 4 5 →