2 DISTINCT TRANSCRIPTION FACTORS THAT BIND THE IMMUNOGLOBULIN ENHANCER MU-E5/KE2 MOTIF

被引：429

作者：

HENTHORN, P ^{[1
]}

KILEDJIAN, M ^{[1
]}

KADESCH, T ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT HUMAN GENET,PHILADELPHIA,PA 19104

来源：

SCIENCE | 1990年 / 247卷 / 4941期

关键词：

D O I：

10.1126/science.2105528

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Activity of the immunoglobulin heavy and κ light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted HFP-1 and ITF-2, that are expressed in a variety of cell types and bind the μE5/κE2 motif found in both heavy and κ light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.

引用

页码：467 / 470

页数：4