Nitrosative and oxidative modulation of iron regulatory proteins

被引：31

作者：

Bouton, C ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91190 Gif Sur Yvette, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 55卷 / 8-9期

关键词：

nitric oxide; redox modulation; iron metabolism; gene regulation;

D O I：

10.1007/s000180050355

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokine-driven nitric oxide (NO) synthase II provides cells with effecters for reactions at redox-sensitive site(s) of proteins. Iron regulatory proteins (IRP1 and IRP2), two post-transcriptional regulators of gene expression, are particularly sensitive to NO synthesis and to oxidative stress. IRP1 possesses a redox-active Fe-S cluster and can also exhibit aconitase activity. IRP2 has no Fe-S cluster but exhibits several redox-sensitive cysteine residues. Under proper redox conditions, both IRPs bind to iron-responsive elements in the untranslated region of mRNAs encoding proteins involved in iron metabolism and energy production. This review describes and compares the effects of NO, peroxynitrite, and reactive oxygen species on these two chemosensitive proteins.

引用

页码：1043 / 1053

页数：11

共 95 条

[1] IRON REGULATES FERRITIN MESSENGER-RNA TRANSLATION THROUGH A SEGMENT OF ITS 5' UNTRANSLATED REGION [J].

AZIZ, N ;

MUNRO, HN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8478-8482

[2] THE IRON-RESPONSIVE ELEMENT-BINDING PROTEIN - LOCALIZATION OF THE RNA-BINDING SITE TO THE ACONITASE ACTIVE-SITE CLEFT [J].

BASILION, JP ;

ROUAULT, TA ;

MASSINOPLE, CM ;

KLAUSNER, RD ;

BURGESS, WH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :574-578

[3]

BEAUMONT C, 1994, J BIOL CHEM, V269, P20281

[4] Peroxynitrite augments fMLP-stimulated chemiluminescence by neutrophils in human whole blood [J].

Bednar, MM ;

Balazy, M ;

Murphy, M ;

Booth, C ;

Fuller, SP ;

Barton, A ;

Bingham, J ;

Golding, L ;

Gross, CE .

JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 60 (05) :619-624

[5] ACONITASE, A 2-FACED PROTEIN - ENZYME AND IRON REGULATORY FACTOR [J].

BEINERT, H ;

KENNEDY, MC .

FASEB JOURNAL, 1993, 7 (15) :1442-1449

[6] EVIDENCE THAT THE PATHWAY OF TRANSFERRIN RECEPTOR MESSENGER-RNA DEGRADATION INVOLVES AN ENDONUCLEOLYTIC CLEAVAGE WITHIN THE 3' UTR AND DOES NOT INVOLVE POLY(A) TAIL SHORTENING [J].

BINDER, R ;

HOROWITZ, JA ;

BASILION, JP ;

KOELLER, DM ;

KLAUSNER, RD ;

HARFORD, JB .

EMBO JOURNAL, 1994, 13 (08) :1969-1980

[7] Modulation of iron regulatory protein functions - Further insights into the role of nitrogen- and oxygen-derived reactive species [J].

Bouton, C ;

Raveau, M ;

Drapier, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (04) :2300-2306

[8] Redox modulation of iron regulatory proteins by peroxynitrite [J].

Bouton, C ;

Hirling, H ;

Drapier, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (32) :19969-19975

[9] Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages [J].

Bouton, C ;

Oliveira, L ;

Drapier, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) :9403-9408

[10] Differences in the RNA binding sites of iron regulatory proteins and potential target diversity [J].

Butt, J ;

Kim, HY ;

Basilion, JP ;

Cohen, S ;

Iwai, K ;

Philpott, CC ;

Altschul, S ;

Klausner, RD ;

Rouault, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :4345-4349

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