Nitrosative and oxidative modulation of iron regulatory proteins

被引：31

作者：

Bouton, C ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91190 Gif Sur Yvette, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 55卷 / 8-9期

关键词：

nitric oxide; redox modulation; iron metabolism; gene regulation;

D O I：

10.1007/s000180050355

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokine-driven nitric oxide (NO) synthase II provides cells with effecters for reactions at redox-sensitive site(s) of proteins. Iron regulatory proteins (IRP1 and IRP2), two post-transcriptional regulators of gene expression, are particularly sensitive to NO synthesis and to oxidative stress. IRP1 possesses a redox-active Fe-S cluster and can also exhibit aconitase activity. IRP2 has no Fe-S cluster but exhibits several redox-sensitive cysteine residues. Under proper redox conditions, both IRPs bind to iron-responsive elements in the untranslated region of mRNAs encoding proteins involved in iron metabolism and energy production. This review describes and compares the effects of NO, peroxynitrite, and reactive oxygen species on these two chemosensitive proteins.

引用

页码：1043 / 1053

页数：11

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