Interspecies Recombination Occurs Frequently in Quinolone Resistance-Determining Regions of Clinical Isolates of Streptococcus pyogenes

被引：15

作者：

Duesberg, Christoph B. ^{[1
]}

Malhotra-Kumar, Surbhi ^{[2
]}

Goossens, Herman ^{[2
]}

McGee, Lesley ^{[3
]}

Klugman, Keith P. ^{[3
,4
]}

Welte, Tobias ^{[1
]}

Pletz, Mathias W. R. ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Resp Med, D-30625 Hannover, Germany

[2] Univ Antwerp, Dept Med Microbiol, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium

[3] Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA

[4] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 11期

关键词：

D O I：

10.1128/AAC.00518-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.

引用

页码：4191 / 4193

页数：3

共 9 条

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