The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress

被引：345

作者：

Chakravarthi, S ^{[1
]}

Jessop, CE ^{[1
]}

Bulleid, NJ ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

EMBO REPORTS | 2006年 / 7卷 / 03期

基金：

英国惠康基金;

关键词：

disulphide-bond formation; endoplasmic reticulum; glutathione; oxidative stress; reactive oxygen species;

D O I：

10.1038/sj.embor.7400645

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutathione is a ubiquitous molecule found in all parts of the cell where it fulfils a range of functions from detoxification to protection from oxidative damage. It provides the main redox buffer for cells and as such has been implicated in the formation of native disulphide bonds. However, the discovery of the enzyme Ero1 has called into question the exact role of glutathione in this process. In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide-bond formation and consider its role in protecting the cell from endoplasmic-reticulum-generated oxidative stress.

引用

页码：271 / 275

页数：5

共 32 条

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