Retromer

被引:396
作者
Bonifacino, Juan S. [2 ]
Hurley, James H. [1 ]
机构
[1] NIDDK, Mol Biol Lab, Natl Inst Hlth, Bethesda, MD 20892 USA
[2] NICHHD, Cell Biol & Metab Program, Natl Inst Hlth, Bethesda, MD 20892 USA
关键词
D O I
10.1016/j.ceb.2008.03.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The retromer is a heteropentameric complex that associates with the cytosolic face of endosomes and mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network. The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35. The SNX subunits contain PX and BAR domains that allow binding to PI(3)P enriched, highly curved membranes of endosomal vesicles and tubules, while Vps26, Vps29 and Vps35 have arrestin, phosphoesterase and alpha-solenoid folds, respectively. Recent studies have implicated retromer in a broad range of physiological, developmental and pathological processes, underscoring the critical nature of retrograde transport mediated by this complex.
引用
收藏
页码:427 / 436
页数:10
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