Structural analysis of α-carrageenan sulfated oligosaccharides by positive mode nano-ESI-FTICR-MS and MS/MS by SORI-CID

被引：20

作者：

Aguilan, JT

Dayrit, FM

Zhang, JH

Niñonuevo, MR

Lebrilla, CB

机构：

[1] Ateneo Manila Univ, Dept Chem, Quezon City 1108, Philippines

[2] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2006年 / 17卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.jasms.2005.09.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural analysis of sulfated oligosaccharides from K-carrageenan of up to ten residues (MW > 2 kDa) was successfully carried out by positive mode nano-ESI-FTICR-MS together with MS/MS using sustained off-resonance irradiation-collision induced dissociation (SORI-CID). Glycosidic bond cleavage reactions via the B- and Y-types of fragmentation were observed and enabled complete sequencing of the oligosaccharide samples. The positions of the labile sulfate substituents were observable using SORI-CID, enabling the determination of the sequence of the sulfated residues.

引用

收藏

页码：96 / 103

页数：8

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